Episode 18: Patellofemoral Pain Syndrome- Risk Factors, Etiology, and Effective Rehab Evidence

By Nancy Krause
March 7, 2026

Patellofemoral Pain Syndrome (PFPS) remains one of the most common—and frustrating—conditions clinicians treat. On this episode University Orthopedics PT Podcast, host Dan Bien sits down with University of Connecticut’s Neal Glaviano, PhD, ATC, to unpack the science, challenge outdated assumptions, and clarify what actually works in rehab.

From biomechanics and motor control to bracing, BFR, and exercise selection, this conversation delivers practical insights grounded in research.


Listen to the full episode of the PT Podcast with Dan Bien featuring Dr. Neal Glaviano to dive deeper into evidence-based strategies for managing patellofemoral pain.

Timecodes:

1:03 – Dr. Neal Glaviano Bio

3:12 – Pain Generator in Patellofemoral Pain
• Patellofemoral contact area & joint stress
• Subchondral bone involvement

5:56 – “Chicken or Egg?” Quad vs. Glute Inhibition
• Pain-driven inhibition vs. altered biomechanics
• Population differences (military data)
• Quad strength as a risk factor
• Hip strength considerations

9:07 – Gender Differences in PF Pain
• Higher prevalence in females
• Subgroups
• Individual variability

11:44 – Motor Pattern Compensations
• Multi-planar deviations
• Dynamic knee valgus
• Fear avoidance & motor strategies

15:12 – Motor Control & Retraining

19:45 – Risk Factors & Susceptibility

20:52 – Intervention Strategies: Quad & Glute Strengthening
• Why clamshells aren’t the solution
• VMO isolation myths
• Gluteus medius focus
• Gluteus maximus (tri-planar loading)

26:10 – Orthotics

27:00 – Patellar Bracing & Taping
• Lateral J brace
• Symptom control & proprioception

29:49 – Blood Flow Restriction (BFR) in PF Rehab

33:00 – Exercise Selection
• Open vs. closed chain
• Pain monitoring (VAS)
• Strength & power-based progressions

36:00 – NMES for Patellofemoral Pain
• Quad NMES
• Glute NMES

40:06 – Motor Retraining
• Scaling
• Retention

41:07 – Closed Chain Loading Guidelines
• Framework & modifications

44:24 – Research Gaps in Patellofemoral Pain

47:40 – Upcoming Professional Projects

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